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1

1,7- and 2,7-naphthyridine derivatives as potent and highly specific PDE5 inhibitors

Tatsuzo Ukita, Yoshinori Nakamura, Akira Kubo, Yasuo Yamamoto, Yasunori Moritani, Kunio Saruta, Takanori Higashijima, Jun Kotera, Kotomi Fujishige, Michino Takagi, Kohei Kikkawa, Kenji Omori

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 239 KB

english, 2003

2

Rotational acetabular osteotomy for severely dysplastic acetabulum

M. Nozawa, Katsuo Shitoto, Tomohiko Hirose, Keiji Matsuda, Kunio Michino, Hajime Kajihara, Katsuhiko Maezawa, Hisashi Kurosawa

Journal:

Archives of Orthopaedic and Trauma Surgery

Year:

2000

Language:

english

File:

PDF, 179 KB

english, 2000

3

[IEEE SICE 2008 - 47th Annual Conference of the Society of Instrument and Control Engineers of Japan - Chofu (2008.08.20-2008.08.22)] 2008 SICE Annual Conference - High gain adaptive output feedback control of nonlinear systems with some uncertainties in control input term

Michino, Ryuji, Mizumoto, Ikuro

Year:

2008

Language:

english

File:

PDF, 252 KB

english, 2008

4

Computational approaches to detect allosteric pathways in transmembrane molecular machines

Stolzenberg, Sebastian, Michino, Mayako, LeVine, Michael V., Weinstein, Harel, Shi, Lei

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

2016

Language:

english

File:

PDF, 1.47 MB

english, 2016

5

Massive Outbreak of Escherichia coli O157: H7 Infection In Schoolchildren in Sakai City, Japan, Associated with Consumption of White Radish Sprouts

Michino, H., Araki, K., Minami, S., Takaya, S., Sakai, N., Miyazaki, M., Ono, A., Yanagawa, H.

Journal:

American Journal of Epidemiology

Year:

1999

Language:

english

File:

PDF, 765 KB

english, 1999

6

Quantifying shoreline change in Funafuti Atoll, Tuvalu using a time series of Quickbird, Worldview and Landsat data

Hisabayashi, Michino, Rogan, John, Elmes, Arthur

Journal:

GIScience & Remote Sensing

Year:

2017

Language:

english

File:

PDF, 1.44 MB

english, 2017

7

The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions

Draper-Joyce, Christopher J., Verma, Ravi Kumar, Michino, Mayako, Shonberg, Jeremy, Kopinathan, Anitha, Klein Herenbrink, Carmen, Scammells, Peter J., Capuano, Ben, Abramyan, Ara M., Thal, David M., J

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 1.87 MB

english, 2018

8

Palladium-Catalyzed Cyanation of CarbonCarbon Triple Bonds Under Aerobic Conditions

Shigeru Arai, Takashi Sato, Yuka Koike, Michino Hayashi, Atsushi Nishida

Journal:

Angewandte Chemie

Year:

2009

Language:

english

File:

PDF, 321 KB

english, 2009

9

Palladium-Catalyzed Cyanation of CarbonCarbon Triple Bonds Under Aerobic Conditions

Shigeru Arai, Takashi Sato, Yuka Koike, Michino Hayashi, Atsushi Nishida

Journal:

Angewandte Chemie International Edition

Year:

2009

Language:

english

File:

PDF, 321 KB

english, 2009

10

ChemInform Abstract: Palladium-Catalyzed Cyanation of Carbon—Carbon Triple Bonds under Aerobic Conditions.

Shigeru Arai, Takashi Sato, Yuka Koike, Michino Hayashi, Atsushi Nishida

Journal:

Year:

2009

File:

PDF, 66 KB

2009

11

Formation of RuII-alkyl-butadiene complexes from dihalogeno-RuIV-allyl precursors by the reaction with BrMg(CH2)4MgBr: a novel decomposition pathway for ruthena(IV)cyclopoentane intermediates

Hideo Nagashima, Yoshiyuki Michino, Ken-ichi Ara, Takahiko Fukahori, Kenji Itoh

Journal:

Journal of Organometallic Chemistry

Year:

1991

Language:

english

File:

PDF, 522 KB

english, 1991

12

Demonstration of A antigen and A allele of ABO histo-blood group in nail in a case with the absence of A antigen and anti-A antibody in blood

Junko Michino, Yukiko Hata, Kazuhiro Matsui, Hisao Takizawa, Yoshihiko Kominato, Sachiyo Tabata, Kazuma Nishino, Satoshi Yasumura, Isao Kitajima

Journal:

Year:

2005

Language:

english

File:

PDF, 138 KB

english, 2005

13

Transcription starting from an alternative promoter leads to the expression of the human ABO histo-blood group antigen

Yukiko Hata, Yoshihiko Kominato, Hisao Takizawa, Sachiyo Tabata, Junko Michino, Kazuma Nishino, Satoshi Yasumura, Fumiichiro Yamamoto

Journal:

Transfusion (Wiley)

Year:

2003

Language:

english

File:

PDF, 171 KB

english, 2003

14

Improved model building and assessment of the Calcium-sensing receptor transmembrane domain

Lintao Bu, Mayako Michino, Romain M. Wolf, Charles L. Brooks III

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2008

Language:

english

File:

PDF, 529 KB

english, 2008

15

Predicting structurally conserved contacts for homologous proteins using sequence conservation filters

Mayako Michino, Charles L. Brooks III

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2009

Language:

english

File:

PDF, 403 KB

english, 2009

16

FoldGPCR: Structure prediction protocol for the transmembrane domain of G protein-coupled receptors from class A

Mayako Michino, Jianhan Chen, Raymond C. Stevens, Charles L. Brooks III

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2010

Language:

english

File:

PDF, 405 KB

english, 2010

17

Effects of dexmedetomidine on cerebral circulation and systemic hemodynamics after cardiopulmonary resuscitation in dogs

Hiroki Iida, Mami Iida, Hiroto Ohata, Tomohiro Michino, Shuji Dohi

Journal:

Journal of Anesthesia

Year:

2006

Language:

english

File:

PDF, 438 KB

english, 2006

18

Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008

Michino, Mayako, Abola, Enrique, Brooks, Charles L., Dixon, J. Scott, Moult, John, Stevens, Raymond C.

Journal:

Nature Reviews Drug Discovery

Year:

2009

Language:

english

File:

PDF, 782 KB

english, 2009

19

Molecular Determinants of Selectivity and Efficacy at the Dopamine D3 Receptor

Newman, Amy Hauck, Beuming, Thijs, Banala, Ashwini K., Donthamsetti, Prashant, Pongetti, Katherine, LaBounty, Alex, Levy, Benjamin, Cao, Jianjing, Michino, Mayako, Luedtke, Robert R., Javitch, Jonatha

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 3.12 MB

english, 2012

20

Non-stoichiometry in yttrium ortho-vanadate

T. Katsumata, H. Takashima, T. Michino, Y. Nobe

Journal:

Materials Research Bulletin

Year:

1994

Language:

english

File:

PDF, 418 KB

english, 1994

21

University of the Pacific/Highland Hospital Oral and Maxillofacial Surgery Training Program

James M. Michino, Felice O'Ryan, Alexis Kleinman, A. Thomas Indresano

Journal:

Journal of Oral and Maxillofacial Surgery

Year:

2011

Language:

english

File:

PDF, 2.13 MB

english, 2011

22

Antiplatelet mechanisms of TA-993 and its metabolite MB3 in ADP-induced platelet aggregation

Makoto Katoh, Tadashi Karasawa, Hisayoshi Doi, Akio Odawara, Michino Takagi, Tomihiro Ikeo, Hiroshi Narita

Journal:

European Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 294 KB

english, 2000

23

Pharmacological profile of T-1032, a novel specific phosphodiesterase type 5 inhibitor, in isolated rat aorta and rabbit corpus cavernosum

Michino Takagi, Hideki Mochida, Tsunehisa Noto, Koji Yano, Hirotaka Inoue, Tomihiro Ikeo, Kohei Kikkawa

Journal:

European Journal of Pharmacology

Year:

2001

Language:

english

File:

PDF, 194 KB

english, 2001

24

Sildenafil and T-1032, phosphodiesterase type 5 inhibitors, showed a different vasorelaxant property in the isolated rat aorta

Hideki Mochida, Hirotaka Inoue, Michino Takagi, Tsunehisa Noto, Koji Yano, Kohei Kikkawa

Journal:

European Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 191 KB

english, 2002

25

Enzymological and pharmacological profile of T-0156, a potent and selective phosphodiesterase type 5 inhibitor

Hideki Mochida, Michino Takagi, Hirotaka Inoue, Tsunehisa Noto, Koji Yano, Kotomi Fujishige, Takashi Sasaki, Keizo Yuasa, Jun Kotera, Kenji Omori, Kohei Kikkawa

Journal:

European Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 158 KB

english, 2002

26

Modification by cyclopiazonic acid and ryanodine of depolarization-induced constriction in rat mesenteric artery

Kiyokazu Naganobu, Michino Takagi, Hiromu Kawasaki, Katsuaki Ito

Journal:

European Journal of Pharmacology

Year:

1994

Language:

english

File:

PDF, 390 KB

english, 1994

27

The effect of para-nonylphenol on Japanese eel (Anguilla japonica) spermatogenesis in vitro

C. Miura, N. Takahashi, F. Michino, T. Miura

Journal:

Aquatic Toxicology

Year:

2005

Language:

english

File:

PDF, 602 KB

english, 2005

28

4. CMAP derived from proximal and distal muscle by stimulating Erb point and CMCT in cervical spondylotic amyotrophy

Ayumi Igaki, Fumiaki Okada, Miho Kuroda, Michino Honda, Saori Shibayama, Koji Inuzumi, Yasunao Wada, Tokuhide Moriyama, Shinichi Yoshiya, Masahiro Koshiba

Journal:

Clinical Neurophysiology

Year:

2011

Language:

english

File:

PDF, 35 KB

english, 2011

29

An investigation into intersex amphipods and a possible association with aquaculture

Alex T. Ford, Paul A. Read, Tim L. Jones, Fumiko Michino, Yvonne Pang, Teresa F. Fernandes

Journal:

Marine Environmental Research

Year:

2007

Language:

english

File:

PDF, 738 KB

english, 2007

30

SARS-CoV spike protein-expressing recombinant vaccinia virus efficiently induces neutralizing antibodies in rabbits pre-immunized with vaccinia virus

Masahiro Kitabatake, Shingo Inoue, Fumihiko Yasui, Shoji Yokochi, Masaaki Arai, Kouichi Morita, Hisatoshi Shida, Minoru Kidokoro, Fukashi Murai, Mai Quynh Le, Kyosuke Mizuno, Kouji Matsushima, Michino

Journal:

Year:

2007

Language:

english

File:

PDF, 634 KB

english, 2007

31

Bridging the NFAT and NF-κB Families: NFAT5 Dimerization Regulates Cytokine Gene Transcription in Response to Osmotic Stress

Cristina López-Rodrı́guez, José Aramburu, Lei Jin, Andrew S Rakeman, Mayako Michino, Anjana Rao

Journal:

Year:

2001

Language:

english

File:

PDF, 579 KB

english, 2001

32

Novel, Potent, and Selective Phosphodiesterase 5 Inhibitors: Synthesis and Biological Activities of a Series of 4-Aryl-1-isoquinolinone Derivatives

Ukita, Tatsuzo, Nakamura, Yoshinori, Kubo, Akira, Yamamoto, Yasuo, Moritani, Yasunori, Saruta, Kunio, Higashijima, Takanori, Kotera, Jun, Takagi, Michino, Kikkawa, Kohei, Omori, Kenji

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 316 KB

english, 2001

33

Non-linear association between ankle-brachial pressure index and prevalence of silent cerebral infarction in Japanese patients with type 2 diabetes

Ryotaro Bouchi, Tetsuya Babazono, Michino Takagi, Naoshi Yoshida, Izumi Nyumura, Kiwako Toya, Ko Hanai, Nobue Tanaka, Yasuko Uchigata

Journal:

Atherosclerosis

Year:

2012

Language:

english

File:

PDF, 201 KB

english, 2012

34

T-1032, a novel phosphodiesterase type 5 inhibitor, increases the survival of cardiomyopathic hamsters

Hirotaka Inoue, Koji Yano, Tsunehisa Noto, Michino Takagi, Tomihiro Ikeo, Kohei Kikkawa

Journal:

European Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 285 KB

english, 2002

35

Determination of flow stress by inverse solution using finite element method

M. Michino, M. Tanaka

Journal:

Computational Mechanics

Year:

1995

Language:

english

File:

PDF, 480 KB

english, 1995

36

[IEEE 2008 International Conference on Control, Automation and Systems (ICCAS) - Seoul, South Korea (2008.10.14-2008.10.17)] 2008 International Conference on Control, Automation and Systems - High gain adaptive output feedback control of nonlinear systems with time-varying uncertainties in control input term

Michino, Ryuji, Mizumoto, Ikuro

Year:

2008

Language:

english

File:

PDF, 305 KB

english, 2008

37

A new mechanism of allostery in a G protein–coupled receptor dimer

Lane, J Robert, Donthamsetti, Prashant, Shonberg, Jeremy, Draper-Joyce, Christopher J, Dentry, Samuel, Michino, Mayako, Shi, Lei, López, Laura, Scammells, Peter J, Capuano, Ben, Sexton, Patrick M, Jav

Journal:

Nature Chemical Biology

Year:

2014

Language:

english

File:

PDF, 1.60 MB

english, 2014

38

Robust adaptive control of non-holonomic mobile robots with uncertain constraints

Michino, Ryuji, Mizumoto, Ikuro

Journal:

International Journal of Advanced Mechatronic Systems

Year:

2013

Language:

english

File:

PDF, 563 KB

english, 2013

39

Design and synthesis of novel 5-(3,4,5-trimethoxybenzoyl)-4-aminopyrimidine derivatives as potent and selective phosphodiesterase 5 inhibitors: Scaffold hopping using a pseudo-ring by intramolecular hydrogen bond formation

Sakamoto, Toshiaki, Koga, Yuichi, Hikota, Masataka, Matsuki, Kenji, Murakami, Michino, Kikkawa, Kohei, Fujishige, Kotomi, Kotera, Jun, Omori, Kenji, Morimoto, Hiroshi, Yamada, Koichiro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.47 MB

english, 2014

40

The discovery of avanafil for the treatment of erectile dysfunction: A novel pyrimidine-5-carboxamide derivative as a potent and highly selective phosphodiesterase 5 inhibitor

Sakamoto, Toshiaki, Koga, Yuichi, Hikota, Masataka, Matsuki, Kenji, Murakami, Michino, Kikkawa, Kohei, Fujishige, Kotomi, Kotera, Jun, Omori, Kenji, Morimoto, Hiroshi, Yamada, Koichiro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 2.52 MB

english, 2014

41

A novel HLA-B allele, HLA-B*39:01:16 , identified by super high-resolution single-molecule sequence-based typing in a Japanese individual

Miyazono, T., Shiina, T., Michino, J., Yasumura, S., Sugiyama, T.

Journal:

Tissue Antigens

Year:

2013

Language:

english

File:

PDF, 556 KB

english, 2013

42

Fluctuations in HbA1c are associated with a higher incidence of cardiovascular disease in Japanese patients with type 2 diabetes

Bouchi, Ryotaro, Babazono, Tetsuya, Mugishima, Michino, Yoshida, Naoshi, Nyumura, Izumi, Toya, Kiwako, Hayashi, Toshihide, Hanai, Ko, Tanaka, Nobue, Ishii, Akiko, Iwamoto, Yasuhiko

Journal:

Journal of Diabetes Investigation

Year:

2012

Language:

english

File:

PDF, 276 KB

english, 2012

43

A novel HLA-B allele, HLA-B*44:184 , identified by super high-resolution single-molecule sequence-based typing in a Japanese individual

Wada, A., Shiina, T., Michino, J., Yasumura, S., Sugiyama, T.

Journal:

Tissue Antigens

Year:

2014

Language:

english

File:

PDF, 178 KB

english, 2014

44

Presence of nucleotide substitutions in transcriptional regulatory elements such as the erythroid cell-specific enhancer-like element and the ABO promoter in individuals with phenotypes A 3 and B 3 , respectively

Takahashi, Y., Isa, K., Sano, R., Nakajima, T., Kubo, R., Takahashi, K., Kominato, Y., Michino, J., Masuno, A., Tsuneyama, H., Ito, S., Ogasawara, K., Uchikawa, M.

Journal:

Year:

2014

Language:

english

File:

PDF, 520 KB

english, 2014

45

What Can Crystal Structures of Aminergic Receptors Tell Us about Designing Subtype-Selective Ligands?

Michino, M., Beuming, T., Donthamsetti, P., Newman, A. H., Javitch, J. A., Shi, L.

Journal:

Pharmacological Reviews

Year:

2014

Language:

english

File:

PDF, 2.37 MB

english, 2014

46

Obesity as an effect modifier of the association between leptin and diabetic kidney disease

Hanai, Ko, Babazono, Tetsuya, Takagi, Michino, Yoshida, Naoshi, Nyumura, Izumi, Toya, Kiwako, Tanaka, Nobue, Uchigata, Yasuko

Journal:

Journal of Diabetes Investigation

Year:

2014

Language:

english

File:

PDF, 310 KB

english, 2014

47

Albuminuria and reduced glomerular filtration rate for predicting the renal outcomes in type 2 diabetic patients

Tanaka, Nobue, Babazono, Tetsuya, Takagi, Michino, Yoshida, Naoshi, Toya, Kiwako, Nyumura, Izumi, Hanai, Ko, Uchigata, Yasuko

Journal:

Year:

2015

Language:

english

File:

PDF, 1.05 MB

english, 2015

48

Structural basis for Na + -sensitivity in dopamine D2 and D3 receptors

Michino, Mayako, Free, R. Benjamin, Doyle, Trevor B., Sibley, David R., Shi, Lei

Journal:

Chemical Communications

Year:

2015

Language:

english

File:

PDF, 726 KB

english, 2015

49

A Single Glycine in Extracellular Loop 1 Is the Critical Determinant for Pharmacological Specificity of Dopamine D2 and D3 Receptors

Michino, M., Donthamsetti, P., Beuming, T., Banala, A., Duan, L., Roux, T., Han, Y., Trinquet, E., Newman, A. H., Javitch, J. A., Shi, L.

Journal:

Molecular Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.45 MB

english, 2013

50

Effect of Unilateral Section of Cervical Afferent Nerve upon Optokinetic Response and Vestibular Nystagmus Induced by Sinusoidal Rotation in Guinea Pigs

Ishikawa, Zensei Matsuzaki, Michino, Kazuo

Journal:

Acta Oto-Laryngologica

Year:

1998

Language:

english

File:

PDF, 123 KB

english, 1998